At the 2005 Latin Grammy Awards

At the 2005 Latin Grammy Awards, Juanes won three additional awards to his nine previous Grammy awards. He took the award for Best Rock Song for "Nada valgo sin tu amor" ("I Am Worthless Without Your Love"), Best Rock Solo Album for Mi sangre and Best Music Video for "Volverte a ver" ("To See You Again"). On December 9, 2005, Juanes performed "La camisa negra" at an international gala in Germany celebrating the 2006 FIFA World Cup Final Draw evening. In 2006, he recorded a duet of " The Shadow of Your Smile" with Tony Bennett for Bennett's Duets an American Classic

In June 2006, Juanes began a year-long sabbatical to spend time with his wife, model Karen Martínez, and their daughters Luna and Paloma. He was working on an album that was released on October 23 2007. When asked about the possibility of recording an album in English, Juanes responded, "singing in Spanish is very important because it's the language in which I think and feel. I respect people that sing in English, but for now I'll keep my Spanish. "Juanes planned to launch his own music label, named 4J, in October 2007, to be distributed by the Universal Music Group. He also was working on a new album, titled “ La vida es un ratico “ (Life Is a Little Moment).

“La vida es un ratico" was released on Oct 23, 2007 with the first single being "Me Enamora" (it makes me fall in love). The second single was "Gotas de Agua Dulce" (drops of sweet water), and the third single became the vallenato fusion of "Tres" (three).